Thursday, October 22, 2009

Drug Discovery and Evaluation: Pharmacological Assays

The rapid progress in biology will continue to change the methodological approach to drug discovery in the coming years. Electronic media will continuously help researchers to access and share information. It is, however, becoming more and more evident that many young pharmacologists have only limited training in classical pharmacological methodologies. These long-standing and still highly relevant methods are simply not available in the electronic databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this gap by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies.

The classical methods and the newest technologies, all in one book!

The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.

For this third edition, all existing chapters have been revised and completely updated. A large number of assays were added: we are now publishing two volumes. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis (formerly called activity of blood constituents), - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity.

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Friday, October 9, 2009

Principles of Immunopharmacology


Principles of Immunopharmacologyby Frans P. Nijkamp, Michael J. Parnham (Editors)

Paperback: 662 pages

Publisher: Birkhauser; 2 edition (December 22, 2005)

ISBN: 3764358041Book

Description

This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This second edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition

Drug Therapy for Gastrointestinal Disease


Drug Therapy for Gastrointestinal Disease Publisher:Informa HealthCare Pages:300 2001-05 ISBN:1853177334 PDF 1.3 MBThis book is an invaluable clinical reference for the therapeutic management of gastrointestinal and liver diseases which the gastroenterologist and trainee encounter in their practice. Various drugs and their interactions with their intended site and also with other drugs are discussed from a practical point of view. This book is not a treatise on gastrointestinal pharmacology but a practical guide to the therapeutic use of GI drugs.

Targeted Radionuclide Tumor Therapy: Biological Aspects






Targeted Radionuclide Tumor Therapy: Biological AspectsPublisher: Springer Language: English ISBN:1402086954 402 pages Data: 2007 PDF 5 Mb


Description:
The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book "Targeted Radionuclide Tumor Therapy – Biological aspects" was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. It also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics and basic cell biology.It is the ambition of the editors to enable deeper insights in the process of improving targeted therapy. We believe that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.


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Clinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease


Clinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease Publisher:Informa HealthCare Pages:400 2008-04-08 ISBN:1841846392 PDF 5.1 MBAtherothrombotic disease is the leading cause of morbidity and mortality; therefore, anti-thrombotic agents play a pivotal role in primary and secondary prevention of atherothrombotic complications. In A Clinical Guide to the Use of Antithrombotic Drugs, three main sections in the field have been elaborated. In the first, 3 chapters on basics concepts of atherothrombosis are examined. The objectives of these chapters are to provide pathophysiological concepts on atherothrombosis useful to the practicing clinician to understand the rationale for using antithrombotic agents in daily practice. In the second section, 16 chapters describe 4 main categories of antithombotic agents used in clinical practice: oral antiplatelet agents, intravenous antiplatelet agents, thrombin inhibitors, and fibrinolytics. In each category, description and clinical application of currently approved agents as well as agents under clinical investigation are described. The objectives of this section are to provide the stateof the art knowledge on antithrombotic drug use and development. In the third section, a series of 8 chapters examines the application of antithrombotic agents in specific clinical scenarios. The objective of this section is to provide practical insights on how to apply antithrombotic agents in the context of daily clinical scenarios. Overall, this compendium provides a valuable tool for clinicians in their daily clinical practice on how to use currently available antithrombotic agents as well as provide insights on the future development in this field.

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Gene Therapy for Renal Diseases and Transplantation (2008)


Gene Therapy for Renal Diseases and TransplantationPublisher: S. Karger AG Language: English ISBN: 3805585055 110 pages Data: 2008 PDF 2 Mb
Description:
Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. In the present book, world-renowned experts are presenting new insights into viral and non-viral systems used to effect gene delivery, one chapter being dedicated to the new field of RNA interference (RNAi). This latter method may be successfully used in renal ischemia-reperfusion injury, trauma and transplantation. In the near future, gene therapy might also prove to be a new strategy to target molecules involved in tissue damage and inflammation processes that underlie ARF. So far, gene transfer has been successfully applied in experimental glomerulonephritis and interstitial fibrosis, and studies in larger animals are keenly awaited. Also covered are issues related to transplantation, which is the therapy of choice in many end-stage organ failures. Transfer of genes whose protein products have immunomodulatory properties have proven beneficial in treating acute and chronic graft rejection, one of the problems not satisfactorily solved by current anti-rejection drugs. Gene therapy thus may become a reality in clinical transplantation once its efficacy in larger animals has been demonstrated. Last but not least, a possible benefit of targeted gene therapy in renal cancer or HIV-associated nephropathy is explored. Covering a wide spectrum of topics, this publication provides a valuable overview of current developments and issues.
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Fibrinolytic Therapy in Clinical Practice


Fibrinolytic Therapy in Clinical Practice Publisher:Informa Healthcare Pages:256 2003-07-31 ISBN: 1841840815 PDF 2.7 MBOne of the major breakthroughs in the treatment of cardiovascular disease is the introduction of fibrinolytic therapy. Better knowledge of the pathogenesis of acute ischemic syndromes has identified acute thrombosis as the triggering event in most cases. Thrombosis of large and small arteries may have catastrophic consequences as sudden death, myocardial infarction, ischemic stroke, pulmonary embolism and acute limb necrosis. Fibrinolytic therapy is aimed at early restoration of occluded blood vessels, thus improving symptoms and organ recovery, reducing infarct size and improving quantity and quality of life. However, fibrinolytic drugs have severe, sometimes fatal side-effects. These center on bleeding, sometimes fatal cerebral bleeding. Therefore, stringent patient selection is mandatory; age, time to treatment, relative and absolute contraindications and comitant medication are of utmost importance for safe and efficacious fibrinolysis.

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WHO Model Prescribing Information: Drugs Used in Bacterial Infections





WHO Model Prescribing Information: Drugs Used in Bacterial Infections Publisher:World Health Organisation Pages:184 2001-01-07 ISBN: 9241401079 PDF 6.9 MB
Provides model prescribing information for essential drugs used in the treatment of bacterial infections. This new volume includes drugs used for treating respiratory, gastrointestinal, urinary, perioral, dental and cardiovascular infections, as well as septicaemia and infections of the skin, soft tissues, bones and joints, sexually transmitted diseases, and other commonly encountered bacterial infections. It also covers prophylaxis against rheumatic fever, meningitis, and bacterial infection during surgery.

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Dermatology Therapy: A to Z Essentials


Paperback: 700 pagesData: February 12, 2004Format: PDFDescription: This new title in the Springer series "A to Z Essentials" contains nearly 1000 entries on dermatologic definitions, differential diagnoses and therapeutic possibilities. The highly structured articles include succinct discussions of the signs, symptoms and therapeutic options, including designations of therapies of choice, where appropriate. The volume is richly illustrated in color and contains many tables outlining commonly used medications in dermatology for ease of reference.
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Pain Medicine and Management: Just the Facts


Paperback: 416 pages
Data: May 7, 2004
Format: PDF
Description: A quick reference to the management of pain for specialists as well as general medical practitioners and residents. Written in a concise bulleted format, the content is limited to only the essential facts necessary for assessment and treatment of common pain conditions and presentations. A perfect review tool for both the anesthesia and pain medicine board exams.

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Viral Therapy of Human Cancers


Viral Therapy of Human Cancers
Publisher:Informa HealthCare Pages:848 2004-12-28 ISBN:0824759133 PDF 6.2 MB

Featuring contributions from nearly 30 leading authorities, this pioneering work gauges the potential for viruses to act as oncolytic and anti-tumor agents for the treatment of cancers in humans-detailing the cancer-combative properties exhibited by viruses in nature, genetically engineered viruses, and viral oncolysates as evidenced in basic and experimental studies.




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Acid-Base Disorders and Their Treatment


Acid-Base Disorders and Their Treatment
Publisher:Informa HealthCare Pages:880 2005-08-09 ISBN:082475915X PDF 10.3 MB

With detailed contributions and research from experts in the physiology of normal acid-base homeostasis and the management of acid-base disorders, this reference supplies an abundance of information on acid-base physiology, disorders of acid-base equilibrium, and the management and treatment of these disorders in clinical practice. A unique and timely source, this guide provides a large number of tables, references, and figures to illustrate the relationship between the underlying physiology and diagnosis of acid-base disorders.




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Pharmacology and Therapeutics of Cough (2008)


Pharmacology and Therapeutics of Cough
Publisher: Springer Language: English ISBN: 3540798412 376 pages Data: 2008 PDF 6 Mb

Description: The last decade has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the pharmacological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the voluntary control of cough. This book shows that basic studies are pointing to many potentially valuable approaches to the treatment of cough, based on understanding the basic peripheral receptor mechanisms, the brainstem pathways in the control of cough, and the sensitization processes that may apply in disease.


Cancer Chemotherapy Drug Manual 2008


Physician's Cancer Chemotherapy Drug Manual 2008
Jones and Bartlett Publishers Pages:552 2007-12-28 ISBN:0763755621 PDF 3 MB

Completely revised and updated for 2008, this practical handbook is an up-to-date guide to all aspects of cancer chemotherapy. The book provides a comprehensive, easy to use catalogue of over 100 drugs-both on- and off-label-commonly used in cancer treatment. A section on Common Chemotherapy Regimens provides a quick reference to management of specific cancers, arranged alphabetically.



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Drugs for the Treatment of Respiratory Diseases


Drugs for the Treatment of Respiratory Diseases
Publisher:Cambridge University Press Pages:612 2003-03-24 ISBN: 0521773210 PDF 6.6 MB

Millions of people are affected by these diseases, and the re-emergence of tuberculosis and increase in asthma in certain populations underline the importance of finding effective treatments. The demographice make this a critical time to identify novel strategies to prevent and treat these increasingly common diseases. The volume surveys and evaluates the drug treatments available for the main categories of lung diseases, including asthma, tuberculosis, smoking disorders, lung cancer, and respiratory infections.



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Fundamentals of Clinical Psychopharmacology


Fundamentals of Clinical Psychopharmacology, Second Edition
Publisher:Taylor & Francis Pages:170 2004-08-09 ISBN:1841844276 PDF 1.4 MB

This book brings together leading UK psychiatrists and psychopharmacologists to review and clarify essential information about the scientific background and clinical applications of the drugs used in psychiatry. Based on the excellent Psychopharmacology Course for Psychiatrists in Training, organized twice a year by the British Association for Psychopharmacology, Fundamentals of Clinical Psychopharmacology reflects the individual lectures that make up the course, ranging from basic neuroscience to the analysis of clinical trials. The book is updated regularly, and this Second Edition includes a helpful new chapter on child and adolescent psychopharmacology.

Pharmacogenetics of Breast Cancer


Pharmacogenetics of Breast Cancer: Towards the Individualization of Therapy
Publisher:Informa HealthCare Pages:352 2008-05-19 ISBN:1420052934 PDF 2.8 MB

Pharmacogenetics, generally referred to as the study of genetic variation that gives rise to differing response to drugs, is becoming more relevant in the diagnosis, treatment, and recovery of cancer patients. The problem faced when treating cancer is the outstanding varied efficacy between success and failure. Unpredictability between a population of patients who are affected with the same occurring malignancy can show varying associated toxicities in drug treatment ranging from zero effect through lethal doses. Since the chemotherapeutic agent is often developed to fit the average patient the unfortunate result is that approximately 40% of patients may be receiving the wrong drug. However, using pharmacogenetics there are promising advancements in the development of effective agents which will enable ‘personalized cancer chemotherapy’ to become routine for the clinical practice. This individualization is most advanced in the field of breast cancer; while many breast oncologists are individualizing techniques based on specific profiles, within 10 years it is likely all breast oncologists will be using RT-PCR, FISH-based multiplexed arrays, or a similar testing regime for patient individualization therapy.


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Vaccine Adjuvants: Immunological and Clinical Principles (2005)


Vaccine Adjuvants: Immunological and Clinical Principles
Publisher: Humana Press Language: English ISBN:0896038920 296 pages Data: 2005 PDF 3 Mb

Description: A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.


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Physics, Pharmacology and Physiology for Anaesthetists


Physics, Pharmacology and Physiology for Anaesthetists (US$56)
Stationary Office Pages: 268 2008-05-05 ISBN: 0521700442 3 MB

The FRCA examination relies in part on a sound understanding of the basic sciences (physics, physiology, pharmacology and statistics) behind anaesthetic practice. It is important to be able to describe these principles clearly, particularly in the viva section of the examination. This book provides the reader with all the important graphs, definitions and equations which may be covered in the examination, together with clear and concise explanations of how to present them to the examiner and why they are important. Particular attention is paid to teaching the reader how to draw the graphs. This is an aspect of the examination which can be overlooked but which, if done well, can create a much better impression in the viva situation. Packed full of precise, clear diagrams with well structured explanations, and with all key definitions, derivations and statistics, this is an essential study aid for all FRCA examination candidates.


Targeted Therapies in Oncology


Targeted Therapies in Oncology
Informa Healthcare 2007-09-25 ISBN: 084939371X 424 pages PDF 5,2 Mb

Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere interacting agents, apoptosis inducers, and anti-invasive agents. This book presents an authoritative overview of existing molecular targeted therapies, their relevance and role for specific tumors, and their clinical efficacy and impact on patient treatment.


Gynecological Drug Therapy


Gynecological Drug Therapy
Publisher:Informa Healthcare Pages:336 2006-11-15 ISBN: 0824728416 PDF 2 MB

The most comprehensive and current review available on the wide spectrum of pharmaceuticals used in gynecology and reproductive medicine, this manual provides all-encompassing chapters on specific drugs used in the management of gynecologic oncology and infection, pregnancy, menstrual dysfunction, menopause, and infertility-listing the licensed and commercial names of drugs alongside their mechanisms of action, utilization, benefits, side-effects, and limitations. Setting a gold-standard in the field, this guide is divided into nine top-specific segments for quick-access to material and will be repeatedly referenced by any practitioner caring for the female patient.


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Concise Guide to Psychopharmacology


Lauren B. Marangell, James M., M.D. Martinez “Concise Guide to Psychopharmacology"
American Psychiatric Publishing 2006-03-14 ISBN: 1585622559 260 pages PDF 1,1 Mb

The definitive pocket reference for convenient everyday use.
This invaluable clinical companion begins with an overview of the general principles relevant to the safe and effective use of psychotropic medications. Subsequent chapters focus on the major classes of psychotropic medications and the disorders for which they are prescribed—with the caveat that the nomenclature is somewhat artificial because, for example, many antidepressant medications are also used to treat anxiety disorders.
Updates for this edition in every drug class ensure ready access to information on new drugs and new findings.

Antidepressants—Presents clinically relevant information for selective serotonin reuptake inhibitors, bupropion, venlafaxine, duloxetine, mirtazapine, as well as tricyclic antidepressants and monoamine oxidase inhibitors, including details on choosing one antidepressant over another and discontinuing or switching medications. Updated with new information on the possible risk of increased suicidality and other potential side effects.
Anxiolytics, sedatives, and hypnotics—Discusses the use of benzodiazepines, zolpidem, and zaleplon, and ramelteon for the treatment of insomnia as well as diagnosis-specific guidelines for the use of antidepressants in the treatment of anxiety disorders.

Antipsychotics—Describes the properties common to most antipsychotics, focusing on atypical antipsychotics (clozapine, risperidone, olanzapine, quetiapine, ziprasidone), now used as first-line agents. New in this edition: the latest findings on safety and efficacy, and on the use of antipsychotic agents in bipolar disorder.

Mood stabilizers—-Details the use of lithium, valproate, carbamazepine, lamotrigine, and other anticonvulsants in stabilizing mood oscillations, and expands on the use of antipsychotics for treating bipolar disorder. With new information on the treatment of mania and mixed episodes.

Stimulants—Covers the clinical use, contraindications, risks and side effects, dosing strategies, and monitoring guidelines for methylphenidate hydrochloride, dextroamphetamine, pemoline, and modafinil, used to treat attention-deficit/hyperactivity disorder in children and adolescents, narcolepsy, and (potentially) treatment-resistant depression and cognitive impairment in adults.

Cognitive enhancers—Discusses the clinical use, drug interactions, and side effects of the cholinesterase inhibitors tacrine, donepezil, rivastigmine, and galantamine, which preserve functioning and slow further deterioration in the pharmacological management of cognitive impairment in mild-to-moderate dementia of the Alzheimer's type. Fully updated to reflect the latest findings on the NMDA receptor antagonist memantine.
Packed with practical information that is easy to access via detailed tables and charts, this pocket-sized volume (it literally fits into a lab coat or jacket pocket) is designed to be immediately useful for students, residents, and clinicians working in a variety of treatment settings, such as inpatient psychiatry units, outpatient clinics, consultation-liaison services, and private offices.



Antiarrhythmic Drugs: A Practical Guide


Richard N., MD Fogoros, "Antiarrhythmic Drugs: A Practical Guide"
Wiley-Blackwell 2007-09-17 ISBN: 1405163518 192p PDF 1 Mb


Product Description:

If you prescribe for patients with arrhythmias, you will want to keep this valuable paperback close at hand. The Second Edition of this valuable reference responds to changes in the available medications as well as in the way they are currently used.



The book reviews everything you need to understand and prescribe today’s antiarrhythmic drugs:


mechanisms of cardiac arrhythmias and how antiarrhythmic drugs alter those arrhythmias, including common adverse effects
which factors to consider in using these drugs for treatment of supraventricular tachyarrhythmias, ventricular arrhythmias, and arrhythmias in pregnancy
a detailed review of atrial fibrillation to help you make decisions for patient management in this complicated area


Dr. Fogoros considers all the most recent drugs, plus promising drugs under investigation, to give you a full picture of therapeutic options. With Antiarrhythmic Drugs: A Practical Guide, Second Edition, you will have dependable information on how each drug works and when each one is indicated so you can give your patients the best possible treatment.

Drug Hypersensitivity


W. j. Pichler “Drug Hypersensitivity"
Not Avail 2007-05-31 ISBN: 3805582692 438 pages PDF 6,4 Mb


Drug hypersensitivities are immune-mediated reactions characterized by exanthems, fever and internal organ involvement. They represent a challenging field of research: many different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction, many of which are poorly understood. This is the first book to approach the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced. This publication will be of immense value not only to allergologists, dermatologists and anyone prescribing medication, but also to scientists in a pharmaceutical industry challenged by the economic effects of failures in drug development or drug removal from the market. Elucidating the mechanisms of drug hypersensitivity will not only help to identify patients at risk but will also provide novel insights into the pathophysiology of numerous immune-mediated diseases.



Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances


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David Group, "Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances"
McFarland & Company ISBN 0786408537 2000-12-15 221 Pages PDF 1 Mb

It seems as though every day brings a new pill or potion claiming to restore mental alertness or improve memory. While many of these claims are based on factual information, many others are not. This encyclopedia of foods and drugs that are believed to improve mental performance contains information on nearly 400 nutrients, herbs, and drugs, ranging from ancient plant compounds to the latest pharmaceuticals. Entries are arranged by type of substance, such as foods, vitamins, minerals, spices, and medical drugs. Each entry contains information such as alternate names and forms, sources, results, side effects, precautions, and recommended dosage. Although readers are encouraged to consult with their doctors before diagnosing and treating themselves, this book provides crucial, factual, and unbiased information on the "miracle drugs" that many people believe can solve health problems from fatigue to Alzheimer's. Readers can discover for themselves the properties of each substance. A complete index allows for easy reference and help with alternate names, food and drug interactions, and symptoms.


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Drugs and Human Lactation


Drugs and Human Lactation
Elsevier Science ISBN: 0444819819 1996-11-01 PDF 722 pages 23.6 MB

Now in its second edition, Drugs and Human Lactation is a comprehensive guide to the content and consequences of xenobiotics and micronutrients in human milk, and remains by far the most thorough and extensive work available on this subject. The excellent methodology used for the compilation of the 1st edition has been retained.

It begins with an outline of the processes by which substances enter milk during its formation, the effects of drugs on the milk production process, the main determinants of drug excretion into milk and their disposition in the child. There follows an analysis of current data on 234 individual drugs, describing the extent of their passage into human milk, and assessing the risk to the suckling infant. Vitamins and essential trace elements, and radiopharmaceuticals are similarly reviewed. Also included is an account of the factors that influence the passage of environmental and occupational chemicals into milk. The result is a complete overview of what is known and proven, with clear pointers to matters which require further study, and brings the various subject areas up to date. Risks, uncertainties and false alarms which exist have been defined in such a way that they can be avoided.

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Cancer Vaccines and Tumor Immunity


Rimas Orentas, James W. Hodge, Bryon D., PhD Johnson “Cancer Vaccines and Tumor Immunity"
Wiley-Liss 2008-02-08 ISBN: 0470074744 334 pages PDF 2,3 Mb

Cancer vaccine development has changed from a small-scale academic enterprise in to an applied science requiring a large clinical research infrastructure. In this book, a team of expert contributors take a focused look at the hot emerging area of cancer vaccines and tumor immunity. Cancer Vaccines and Tumor Immunity serves a unique role in that it presents as a continuum the basic science discoveries that have moved forward into clinical trials. It is a one-stop, concise reference for all those interested in cancer vaccines, summarizing where we have come from, demonstrating what we are currently doing, and identifying the next major advances.
Discusses how our new and developing understanding of T-regulatory cells and autoimmunity will impact cancer vaccine design
Offers a unique look forward into how vaccination in the context of bone marrow transplantation will open new avenues for clinical study
Offers an exceptional presentation of how modern genomic analysis of normal and tumor tissue will help to identify the next generation of cancer vaccine targets




Psychotropic Drug Handbook


Paul J Perry , Bruce Alexander, Barry Liskow, C. Lindsay DeVane, "Psychotropic Drug Handbook"
Lippincott Williams & Wilkins; 8 edition (March 1, 2006) ISBN: 0781762731 736 pages CHM 1,6 Mb

This succinct handbook provides students and practitioners with clinically relevant psychotropic drug information. The Eighth Edition is designed as a reference text that also teaches by delivering informative narrative text under standard headlines with references. Its focus goes beyond drug information to cover pharmacotherapy applications. The book provides detailed, well-referenced, evidence-based information on a wide range of psychotropic drugs, including mood stabilizers, antidepressants, and antianxiety agents. This edition has new chapters on pediatric and geriatric psychopharmacotherapy; new content on antipsychotics, hypnotics, medications used in treating alcoholism and substance dependence, and electroconvulsive therapy; and new algorithms, appendices, and tables.

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Cancer Chemotherapy Drug Manual 2006 - CD


Physician's Cancer Chemotherapy Drug Manual 2006 - CD
Jones & Bartlett Publishers - Language: English - ISBN: 0763740195
Format ISO (ISO Maker v1.7) - Size 39.1 MB Aprox.

Book Description
Completely revised and updated for 2006, this practical handbook is an up-to-date guide to all aspects of cancer chemotherapy. The book provides a comprehensive, easy to use catalogue of over 100 drugs-both on- and off-label-commonly used in cancer treatment, including several new agents (recently or about to be FDA approved). A section on Common Chemotherapy Regimens provides a quick reference to management of specific cancers, arranged alphabetically. A comprehensively revised introductory chapter on Principles of Chemotherapy offers a concise, current overview of the field.
Special features include:

• Special chapter profiling anti-emetic drugs

• Diagrams of drug structures and pathways

• Complete discussion of clinical pharmacology, indications, and dosages

• Coverage of toxicity and interactions

• Separate chapter on chemotherapy regimens for specific cancers

• Overview of basic principles of cancer drug therapy

• Easy to load and use CD-ROM version


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2004 Pocket Book of Infectious Disease Therapy


2004 Pocket Book of Infectious Disease Therapy
Author: John G Bartlett John G. Bartlett
Publisher: Lippincott Williams & Wilkins
PDF 336 pages 4,7mb English language ISBN 0781738962


Designed to provide quick access to the standards with which to fight infectious disease by focusing on selection, proper doses, costs, and side effects of antimicrobial agents, the 2004 Pocket Book of Infectious Disease Therapy draws extensively from recommendations made by the Centers for Disease Control, the Medical Letter, the American Hospital Formulary Service, and the AMA's Drug Evaluations. Tabular material has been updated to include all newly approved antibiotics, as well as new recommendations for management.

Johns Hopkins Univ. School of Medicine, Baltimore, MD. Annual pocket-sized reference provides standards of care for the management of infectious diseases with particular emphasis on antimicrobial agents, their selection, dosing regimens, costs, and side effects. Features numerous tabular tables. For physicians and residents.

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Life Saving Drugs: The Elusive Magic Bullet


John Mann "Life Saving Drugs: The Elusive Magic Bullet"
Published by Royal Society of Chemistry November 2004 ISBN : 0854046348 PDF Format, 234 pages English 15.2 MB

In 1900 only a handful of drugs (morphine, quinine, aspirin etc) had genuine efficacy and recovery from infections was haphazard. Now there are literally thousands of drugs and life-threatening infections have been either overcome or much diminished.
Life-saving Drugs: the Elusive Magic Bullet describes the discovery and development of antibacterial, anti-viral and anti-cancer drugs. The book highlights the colourful characters behind the inventions and the huge improvements in quality of life and life-expectancy that these drugs have produced.

Emphasis is given to the new drugs that have emerged as a result of knowledge of the human genome, and the ways in which the newer drugs are being designed to tackle disease, particularly cancer, at the genetic level. Chemical structures are provided for all of the key drugs and the book is well illustrated.

Life-saving Drugs: the Elusive Magic Bullet can be read as a history of drug development during the past 100 years by those with only a passing knowledge of chemistry. For anyone entering the medical profession, pharmacy, or nursing, it will provide a superb basic knowledge of all drugs they are ever likely to meet, including their modes of action. For the chemist or medicinal chemist, it will provide the fundamental knowledge of life-saving drugs that they all should know. And for the non-scientist who wants to know about 'super-bugs', SARS, Ebola, and all of the wonderful advances in treating cancer, it is illuminating and easy to read.

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The Myth of the Chemical Cure: A Critique of Psychiatric Drug Treatment


The Myth of the Chemical Cure
Palgrave Macmillan 2008-02-05 ISBN: 0230574319 296 pages PDF 1 MB

This book exposes the traditional view that psychiatric drugs correct chemical imbalances as a dangerous fraud. It traces the emergence of this view and the way it supported the vested interests of the psychiatric profession, the pharmaceutical industry and the modern state. Instead it is proposed that psychiatric drugs 'work' by creating abnormal brain states, which are often unpleasant and impair normal intellectual and emotional functions along with other harmful consequences. Research on antipsychotics, antidepressants and mood stabilisers is examined to demonstrate this thesis and it is suggested that acknowledging the real nature of psychiatric drugs would lead to a more democratic practice of psychiatry.



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Treatment of Depression: Bridging the 21st Century


Treatment of Depression
American Psychiatric Publishing, Inc. 2001-02 ISBN: 0880483970 357 pages PDF 1,7 MB

The dramatic advances—and controversies—of the past 25 years in understanding the epidemiology and treatment (both pharmacotherapy and psychotherapy), and the health care and delivery issues surrounding major depression are presented in this collection. Divided into four parts, this fascinating volume comprises the contributions of internationally renowned experts from the United States, Switzerland, and the United Kingdom.

* Part I, The Past and the Future, provides an historical and political review of the development and testing of antidepressants, including the controversial role of the pharmaceutical companies in legitimizing depression as a medical illness as a means of creating markets for their products. Also described is depression in the twenty-first century based on studies of the World Health Organization and the World Bank and the inherent conflict in treating depression under managed health care guidelines, i.e., depression, because it tends to recur over a person’s lifetime, mandates more medical care, whereas managed care, because it is structured for profit, mandates less medical care.
* Part II, Basic Understanding, illuminates the role of genetics and basic and clinical biological sciences for developing new treatments as well as the contributions of the neurosciences toward developing new drugs and of psychobiology toward understanding relapse in maintenance treatment.
* Part III, Treatment, describes the broad range of treatments now available in the United States and the United Kingdom for both adults and children (25 years ago, depression was not believed to exist in children); advances in the physical treatment of depression; problems inherent in testing new drugs (the serendipity factor) and the institutional changes necessary to accelerate the process of discovering effective psychotropic drugs; and clinical practice guidelines and how they affect managed care.
* Part IV, Psychotherapy and Evolving Health Care, focuses on the changes required to ensure that psychotherapy remains a reimbursable treatment within managed care, covering the training and use of effective, time-limited treatments. The epilogue highlights the paradox of over- and underuse of psychotherapy for depression, noting that very few of the more than 200 identified therapies have ever been tested and calling for new testing of psychotherapy in comparison or combination with pharmacotherapy.

At once wide-ranging and concise, this volume offers updates on the both medications and the psychotherapies used to treat depression worldwide. As such, it will appeal to a broad audience of psychiatrists, psychologists, social workers, and primary care practitioners.



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The Complete Guide to Psychiatric Drugs: Straight Talk for Best Results


Edward H. Drummond "The Complete Guide to Psychiatric Drugs: Straight Talk for Best Results"
Wiley 2006-06-16 ISBN: 047175062X 352 pages PDF 1 MB


Both easy to use and highly informative, The Complete Guide to Psychiatric Drugs is an indispensable reference for both patients and professionals. Now in a revised and expanded edition, this up-to-date handbook supplies current information on the newest and most commonly used psychiatric drugs as well as the latest details regarding side effects, dosages, and precautions.

Drawing upon his years of experience helping patients understand their illnesses and take charge of their treatments, top expert Dr. Edward Drummond covers vital topics that include:
* Is medication for you?
* What to discuss with your doctor before starting medication
* Do psychiatric drugs pose extra risks for you?
* How to start, monitor, and stop your medication
* Psychiatric syndromes and their treatment

The book also explores non-drug therapies such as dietary treatments, exercise, relaxation techniques, meditation, and self-hypnosis as well as information on how to combine drug, non-drug, and alternative therapies for maximum benefit.

The Complete Guide to Psychiatric Drugs: Straight Talk for Best Results, Revised and Expanded Edition gives you the facts so you can get better, with straight talk on the best new treatments for:
* Anxiety
* Panic Attacks
* Agoraphobia and Phobias
* Obsessive-Compulsive Disorder
* Generalized Anxiety Disorder
* Posttraumatic Stress Disorder
* Attention Deficit/Hyperactivity Disorder
* Bipolar Disorder and Mood Swings
* Depression
* Asperger's Syndrome
* Autism
* Pervasive Developmental Disorder
* Drug Dependence
* Anorexia
* Bulimia
* Binge-Eating Disorder
* Insomnia
* Acute Psychosis
* Schizophrenia
* Schizoaffective Disorder
* Delusional Disorder
* Alzheimer's Disease

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cGMP: Generators, Effectors and Therapeutic Implications


cGMP: Generators, Effectors and Therapeutic Implications (Handbook of Experimental Pharmacology)
Springer 583 pages 2005-08-28 ISBN: 3540689605 PDF 8.86mb

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

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Litt's Drug Eruption Reference Manual Including Drug Interactions


Litt's Drug Eruption Reference Manual Including Drug Interactions, 14th Edition
Publisher:Informa HealthCare Pages:657 2008-01-31 ISBN:0415458854 PDF 3.1 MB

Litt's Drug Eruption Reference Manual, 14th edition, has been updated and improved and incorporates dermatological drug eruptions plus reactions affecting the nails, hair, nails, eyes and mucosal.. This valuable resource also includes herbal and supplements reactions, in addition to hazardous drug-drug interactions. This book is a must have for all dermatologists, general practitioners and those working in emergency medicine.




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Antiepileptic Drugs to Treat Psychiatric Disorders


Antiepileptic Drugs to Treat Psychiatric Disorders (Medical Psychiatry)
Informa Healthcare 2008 ISBN: 0849382599 Pages: 440 PDF 2.07 MB


Several antiepileptic drugs (AEDs) now have pharmaceutical usage for treating bipolar disorder. There is growing evidence that AEDs have mood-stabilizing effects. This book is the first comprehensive, clinically oriented, reference on the use of AEDs to treat a variety of psychiatric disorders such as anxiety disorders, substance use disorders, eating disorders, personality disorders, and neuropsychiatric disorders.

Encyclopedia of Molecular Pharmacology






A fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

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Cancer Chemotherapy and Biotherapy: Principles and Practice


Bruce A Chabner, Dan L Longo,
"Cancer Chemotherapy and Biotherapy: Principles and Practice"

Publisher:Lippincott Williams & Wilkins Pages:1000 2005-11-01 ISBN:0781756286 CHM 14.13 MB

Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics.

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Biology of Depression : From Novel Insights to Therapeutic Strategies (vol. 1 & 2 combined)


Biology of Depression : From Novel Insights to Therapeutic Strategies (vol. 1 & 2 combined)
Wiley-VCH 2005 ISBN: 3527307850 Pages: 1095 PDF 6.44 MB

Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.
This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

Antimicrobial/Anti-Infective Materials: Principles and Applications





Antimicrobial/Anti-Infective Materials: Principles and Applications
By Samuel P. Sawan, Gurusamy Manivannan
Publisher: CRC
Number Of Pages: 346
Publication Date: 1999-12-10
ISBN-10 / ASIN: 1566767946
ISBN-13 / EAN: 9781566767941
Binding: Hardcover
As our consciousness of microbes increases, it appears that our desire to control our interactions with germs also increases in proportion. This is clearly demonstrated by examining the incredible growth in the number and sales volume of consumer products with antimicrobial claims. In the medical field as well, there is much interest in the use of antimicrobial/anti-infective materials for medical devices and general healthcare applications. Antimicrobial/Anti-Infective Materials: Principles, Applications and Devices represents the best current research and practice on ways to reduce infection caused by devices inserted into the human body. This volume presents important recent developments in the research, development, and applications of anti-infective materials for use in medical devices. It includes 15 in-depth reports by more than 40 leading specialists in biomaterials and medical devices that cover a wide range of important advances in various materials and applications. These include improved coatings and surface modifications techniques, improved materials designed for inherent infection resistance, and applications in the areas of cardiac, orthopedic, ENT, and vascular devices. This book serves the information needs of all those involved in the research, development, design, and selection of biomaterials and medical devices. It will benefit anyone who designs, uses, and monitors anti-infective materials, as well as those who develop and apply products made from these materials.


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Manual of Psychiatric Therapeutics


Title:Manual of Psychiatric Therapeutics
Author:Richard I Shader

Publisher:Lippincott Williams & WilkinsPages:5282002-10-28ISBN:0781724708 CHM 1.53 MB

Thoroughly updated in a Third Edition, Dr. Shader's popular Spiral(R) Manual is a practical, authoritative, easy-to-use guide to the diagnosis and treatment of psychiatric disorders. This edition features new chapters on pharmacotherapy for children and youth and on pain management and an expanded chapter on attention-deficit hyperactivity disorder in youth and adults. Coverage also includes complete updates on all psychotropic drugs and an expanded, totally revamped chapter on drug interactions. A new appendix presents a bibliography of algorithms for psychopharmacology and lists Websites to consult for updated iterations. This edition is also available electronically for handheld computers. See Media listing for details.


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Julius A. Vida - Androgens and Anabolic Agents

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Julius A. Vida - Androgens and Anabolic Agents
Academic Press Inc.,U.S. July 1969 ISBN: 0127218505 328 pages PDF 112 MB

This book is a classic, but you will be very hard up to find it anywhere as it is long out of print. If you have an interest in the science of this topic regardless of whether it is medical or athletic it is a must have. Dr. Vida really put a lot of research and useful explanations in this one. Highly suggested reading.

Antiepileptic Drugs: Combination Therapy and Interactions


Antiepileptic Drugs: Combination Therapy and Interactions
Pages: 514 Date: 2005 ISBN:052182219X Rared PDF File Rapidshare & Depositfiles 2 MB


This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed supported by clinical and experimental data. The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuro-pediatricians , psychiatrists and general practitioners.


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Treatments from Toxins - The Therapeutic Potential of Clostridial Neurotoxins


Treatments from Toxins - The Therapeutic Potential of Clostridial Neurotoxins
CRC PRESS, 2007 ISBN: 9780849327094 K. Foster English 318p. 5.5 MB

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New Therapeutic Agents In Thrombosis And Thrombolysis


New Therapeutic Agents In Thrombosis And Thrombolysis
Publisher: CRC 1997-01-15 ISBN: 082479866X Pages: 681 31 MB

Focusing on pharmaceutical agents that have advanced to Phase II of clinical testing or that hold significant promise in the field of therapeutics, this up-to-date resource provides a comprehensive review of the basic mechanisms, clinical developments, and applications of new therapeutic agents in thrombosis and thrombolysis.

Stahl - Essential Psychopharmacology. Neuroscientific Basis and Practical Applications - 2nd. Ed.


Stephen M. Stahl, "Essential Psychopharmacology. Neuroscientific Basis and Practical Applications"
Publisher: Cambridge University Press ISBN-10: 0521646154 2nd. Ed. 2000 PDF 660 pages English 48,5 MB

Stahl's Essential Psychopharmacology has established itself as the preeminent source of education and information in its field. This much expanded second edition enlists advances in neurobiology, and recent clinical developments, to explain with renewed clarity the concepts underlying drug treatment of psychiatric disorders. New neurotransmitter systems, new theories on schizophrenia, clinical advances in antipsychotic and antidepressant therapy, new coverage of attention deficit disorder, sleep disorders and drug abuse, and a new chapter on gender and sexual psychopharmacology - these are all features of this edition. The fully revised text is complemented by many new illustrations, instructive and entertaining as before, and enhanced to reflect new knowledge and topics covered for the first time. The illustrations and their captions may be used independently of the main text for a rapid introduction to the field or for review, and self-assessment tests follow each chapter. Even more, this will be the essential text for students, scientists, psychiatrists and other mental health professionals, enabling them to master the complexities of psychopharmacology, and plan sound treatment approaches based on current knowledge.

Anti-IgE Therapy in Asthma and Allergy


S.H. Arshad, K. Suresh Babu, Stephen Holgate "Anti-IgE Therapy in Asthma and Allergy"
Informa HealthCare 2001-01-15 ISBN: 1841840904 64 pages PDF 1 MB


Little new has been introduced into the armamentarium for asthma therapy in the last thirty years apart from improvements in b2-adrenoceptor agonists, corticosteroids and cysteinyl leukotriene antagonists. However, the introduction of a fully humanised monoclonal antibody to immunoglobulin E (IgE) (omalizumab), should provide a new way of treating allergic disorders, with effects that extend beyond a single affected organ and tissue. The precise role of this new agent in treatment guidelines will need to be carefully evaluated, but its clear efficacy and safety provide a strong statement about the importance of IgE across the full spectrum of allergic disease. This pocketbook provides an illustrative summary of the role of IgE in the pathogenesis of asthma and allied allergic disorders, as well as the effects of anti-IgE therapy in the management of these conditions.

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